Transient lens vacuoles in premature infants

We report 6 cases of bilateral vacuolar lens opacities in premature infants. These uncommon opacities were multiple, located peripherally in the lens, and unrelated to the severity of retinopathy. The vacuoles were transient in nature, did not interfere with ROP examination, and were not adversely affected by antivascular endothelial growth factor treatment. On long-term follow-up, the cataracts had no effect on vision.