کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8965854 | 1646745 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mifepristone reduces hypothalamo-pituitary-adrenal axis activation and restores weight loss in rats subjected to dietary restriction and methylphenidate administration
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
This study evaluates the efficacy of mifepristone on weight restoration in rats subjected to dietary restriction and methylphenidate administration. 25 female rats aged between 9 and 12 months were divided into 2 groups: 5 controls (exposed only to dietary restriction) and 20 rats that were administered 5â¯mg/kg/d of methylphenidate before meal exposure, for 36 days. Among rats who responded to methylphenidate (weight loss of 15-25%) weeks after its administration, a group of 6 rats continued to receive only methylphenidate (“Met” group), and another group received 10â¯mg/kg/d of mifepristone in addition to methylphenidate for 18â¯days (“Met+Mif” group; nâ¯=â¯6). The mean weight of the “Met+Mif” group remained significantly lower when compared to the control group (87.63â¯Â±â¯2.83% vs 96.29â¯Â±â¯3.26%; pâ¯<â¯0.001 respectively) but was significantly higher than that of the “Met” group (87.63â¯Â±â¯2.83% vs. 80.61â¯Â±â¯3.52%; pâ¯<â¯0.001 respectively). Plasma concentrations of adiponectin and gene expression of its receptors in rats brain were significantly higher in the “Met” group as compared to the “Met+Mif” and control groups (pâ¯<â¯0.01). Accordingly, mifepristone reduces HPA axis activation and restores weight through adipose tissue recovering. It might be considered a promising treatment for anorexia nervosa patients in future studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 135, October 2018, Pages 46-53
Journal: Neuroscience Research - Volume 135, October 2018, Pages 46-53
نویسندگان
Rami Bou Khalil, Viviane Smayra, Youakim Saliba, Joelle Hajal, Jules-Joël Bakhos, Lama Souaiby, Sami Richa, Jean Tamraz, Nassim Farès,