کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8966229 1646791 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
RNA-binding proteins as targets for pain therapeutics
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
RNA-binding proteins as targets for pain therapeutics
چکیده انگلیسی
RNA-protein interactions permeate biology. Transcription, translation, processing, and mRNA decay all hinge on widespread use of regulatory information decoded by RNA-binding proteins. The final committed step of protein synthesis, translation, is intimately linked to nociceptor excitability. Understanding the factors that control translation is essential as nociceptor plasticity is a hallmark of persistent pain. Here, we review the growing body of evidence for widespread involvement of RNA-binding proteins in pain. Many of the relevant factors have been implicated in post-transcriptional and translational mechanisms of mRNA control. We propose that recent advances in the development of RNA-based therapeutics provide a potential means to exploit our current understanding of liaisons between RNAs and proteins for therapeutic purposes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Pain - Volume 4, August–December 2018, Pages 2-7
نویسندگان
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