کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8987891 | 1555136 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterisation of lesional infiltrates of dendritic cells and T cell subtypes during primary infestation of sheep with Psoroptes ovis, the sheep scab mite
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کلمات کلیدی
DABmAbTBSPsoroptes ovis3,3′-diaminobenzidine - 3،3'-diaminobenzidineMonoclonal antibody - آنتی بادی مونوکلونالTris buffered saline - تریس نمک بافرRoom temperature - دمای اتاقLymphocyte subpopulations - زیرمجموعه های لنفوسیتT cells - سلول های تیDendritic cells - سلول های دندریتیکconfidence interval - فاصله اطمینانSheep - گوسفند
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Characterisation of lesional infiltrates of dendritic cells and T cell subtypes during primary infestation of sheep with Psoroptes ovis, the sheep scab mite Characterisation of lesional infiltrates of dendritic cells and T cell subtypes during primary infestation of sheep with Psoroptes ovis, the sheep scab mite](/preview/png/8987891.png)
چکیده انگلیسی
Earlier studies of cattle and sheep have demonstrated that Psoroptes ovis infestations provoke an intense immunoinflammatory response dominated by eosinophils accompanied by a substantial infiltrate of lymphocytes. However, the kinetics of the lymphocyte response and the subtypes involved have not been characterised. We employed two groups of sheep to investigate the early (1-21 days) and later (21-63 days) infiltration of lymphocyte subpopulations and dendritic cells in primary infestations of sheep with P. ovis. Immunohistochemistry indicated that by 4 days after infestation numbers of CD4+ and CD45RA+ cells in lesional skin had increased significantly (P < 0.03 and P < 0.005, respectively) and that a significant increase in γδ T cells and dendritic cells (CD1b+) had occurred by 8 days (P < 0.02 and P < 0.01, respectively). Numbers of lymphocyte and dendritic cells declined from 49 to 63 days after infestation. Our observations suggest that mite-derived products exert a profound influence on the early recruitment of lymphocytes that may significantly influence the genesis of the adaptive immune response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 105, Issues 1â2, 1 May 2005, Pages 141-150
Journal: Veterinary Immunology and Immunopathology - Volume 105, Issues 1â2, 1 May 2005, Pages 141-150
نویسندگان
A.H.M. van den Broek, J.F. Huntley, A. Mackellar, J. Machell, M.A. Taylor, H.R.P. Miller,