کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8988694 1555240 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacokinetics of marbofloxacin after intravenous and intramuscular administration to ostriches
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Pharmacokinetics of marbofloxacin after intravenous and intramuscular administration to ostriches
چکیده انگلیسی
The pharmacokinetics of marbofloxacin was investigated after intravenous (IV) and intramuscular (IM) administration, both at a dose rate of 5 mg/kg BW, in six clinically healthy domestic ostriches. Plasma concentrations of marbofloxacin was determined by a HPLC/UV method. The high volume of distribution (3.22 ± 0.98 L/kg) suggests good tissue penetration. Marbofloxacin presented a high clearance value (2.19 ± 0.27 L/kg h), explaining the low AUC values (2.32 ± 0.30 μg h/mL and 2.25 ± 0.70 μg h/mL, after IV and IM administration, respectively) and a short half life and mean residence time (t1/2β = 1.47 ± 0.31 h and 1.96 ± 0.35 h; MRT = 1.46 ± 0.02 h and 2.11 ± 0.30 h, IV and IM, respectively). The absorption of marbofloxacin after IM administration was rapid and complete (Cmax = 1.13 ± 0.29 μg/mL; Tmax = 0.36 ± 0.071 h; MAT = 0.66 ± 0.22 h and F (%) = 95.03 ± 16.89).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 170, Issue 3, November 2005, Pages 364-368
نویسندگان
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