کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8988748 | 1111860 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacokinetics of marbofloxacin after single intravenous and repeat oral administration to cats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pharmacokinetics of marbofloxacin after single intravenous and repeat oral administration to cats Pharmacokinetics of marbofloxacin after single intravenous and repeat oral administration to cats](/preview/png/8988748.png)
چکیده انگلیسی
Serum marbofloxacin disposition was best described by bicompartmental and mono-compartmental open models with first-order elimination after IV and oral dosing respectively. After IV administration, distribution was rapid (T1/2(d) 0.23 ± 0.24 h) and wide, as reflected by the steady-state volume of distribution of 1.01 ± 0.15 L/kg. Elimination from the body was slow with a body clearance of 0.09 ± 0.02 L/h kg and a T1/2 of 7.98 ± 0.57 h. After repeat oral administration, absorption half-life was 0.86 ± 1.59 h and Tmax of 1.94 ± 2.11 h. Bioavailability was almost complete (99 ± 29%) with a peak plasma concentration at the steady-state of 1.97 ± 0.61 μg/mL. Drug accumulation was not significant after six oral administrations. Calculation of efficacy predictors showed that marbofloxacin has good therapeutic profile against Gram-negative and Gram-positive bacteria with a MIC50 value <0.25 μg/mL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 170, Issue 2, September 2005, Pages 222-229
Journal: The Veterinary Journal - Volume 170, Issue 2, September 2005, Pages 222-229
نویسندگان
G.A. Albarellos, L. Montoya, M.F. Landoni,