کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8993395 1113797 2005 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New heterocyclic ligands for the adenosine receptors P1 and for the ATP receptors P2
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
New heterocyclic ligands for the adenosine receptors P1 and for the ATP receptors P2
چکیده انگلیسی
Extracellular adenosine and adenine nucleotides induce various cellular responses through activation of P1 and P2 receptors. P1 receptors preferentially recognize adenosine and four different G protein-coupled receptors (A1, A2A, A2B, and A3 subtypes) have been identified. On the other hand, P2 receptors are activated by adenine and/or uridine nucleotides and classified into two families: ionotropic P2X and G protein-coupled P2Y receptors. In this article, we summarize our studies which led to development of new potent and selective heterocyclic ligands for the adenosine receptors P1 and for the ATP receptors P2X7.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Il Farmaco - Volume 60, Issue 3, March 2005, Pages 185-202
نویسندگان
, , , , , , , ,