کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8994219 | 1114272 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and in vitro evaluation of an extended-release matrix tablet for once-daily oral administration of oxybutynin
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design and in vitro evaluation of an extended-release matrix tablet for once-daily oral administration of oxybutynin Design and in vitro evaluation of an extended-release matrix tablet for once-daily oral administration of oxybutynin](/preview/png/8994219.png)
چکیده انگلیسی
The oral osmotic oxybutynin release system (Oros), allowing once-daily administration, improves the oxybutynin tolerability over the immediate-release formulation. However, Oros manufacture requires a specialized technology. Therefore an attempt was made to design oxybutynin matrix tablets for once-daily administration in the treatment of urinary incontinence. Matrices (weight, 50Â mg; diameter, 6Â mm; dose, 5Â mg) were prepared by compression, and the drug release kinetics in simulated gastric and intestinal fluids (SGF and SIF, respectively) were measured in vitro. Matrices intended to release the drug by diffusion were based on glycerol palmitostearate. This matrix type released the drug only in SGF. In SIF release stopped, due to the conversion, inside the matrix, of the freely water-soluble oxybutynin hydrochloride into the virtually insoluble free base form. Erodible matrices were based on Eudragit L100 (EUD L) or on poly(ethylene oxide) (PEO). Release in SIF from the former was either too slow or non-reproducible, depending on the EUD L fraction in matrix. Erosion-controlled oxybutynin release in SIF from matrices-based on PEO hydrogel was time-independent and depended on polymer MW and on dissolution medium hydrodynamics. A gastroprotected tablet based on a PEO of MW 5000Â kDa released the dose in SIF at the rate of about 6%/h, appropriate for once-daily administration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Drug Delivery Science and Technology - Volume 15, Issue 5, 2005, Pages 397-402
Journal: Journal of Drug Delivery Science and Technology - Volume 15, Issue 5, 2005, Pages 397-402
نویسندگان
Y. Zambito, A. Baggiani, V. Carelli, M.F. Serafini, G. Di Colo,