کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8994292 | 1114277 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular design and morphology of peptide nanotubes: towards the novel drug delivery materials
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
Peptide nanotubes (PNTs) are an artificial protein, being formed by the self-assembly of peptide nanorings (PNRs) consisting of alternate sequences of d- and l-amino acid residues (d,l-peptide). Because they have hollow cores and internal cavities, they are expected to be the novel drug delivery system in the future. Here, in order to give the guiding principle of the molecular design, possible molecular conformations of the peptide nanorings and nanotubes were theoretically investigated and the electronic structures were also studied by ab initio calculations. The syntheses and atomic force microscopy were further performed and the morphology of the peptide nanotubes was investigated experimentally.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Drug Delivery Science and Technology - Volume 15, Issue 1, 2005, Pages 97-107
Journal: Journal of Drug Delivery Science and Technology - Volume 15, Issue 1, 2005, Pages 97-107
نویسندگان
H. Okamoto, K. Takeda,