کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8995707 1115096 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Do vasoactive neuropeptide autoimmune disorders explain pyridostigmine's association with Gulf War syndrome?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Do vasoactive neuropeptide autoimmune disorders explain pyridostigmine's association with Gulf War syndrome?
چکیده انگلیسی
Treatment options involving restoration of VN function are considered in the context of analogues with other neurotransmitter fatigue-related conditions such as myasthenia gravis (MG). While evidence associating these conditions is thin, vasoactive neuropeptide neurotransmitters of the VIP/PACAP family have acetylcholine co-transmission functions via specific GPCRs. Autoimmune reactions to these receptors may have parallels with muscarinic (e.g., Sjogren's syndrome) and nicotinic (e.g., MG) acetylcholine neurotransmission. Hence theoretically, treatment options such as thymectomy, corticosteroids, plasma exchange, anti-idiotype antibodies and receptor genomic expression reactivation/suppression may be considered. Paradoxically pyridostigmine may prove to have a role in therapy although VN treatment/replacement may be associated with tachyphylaxis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 65, Issue 3, 2005, Pages 591-594
نویسندگان
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