Impaired neuronal glucose uptake in pathogenesis of schizophrenia - Can GLUT 1 and GLUT 3 deficits explain imaging, post-mortem and pharmacological findings?

We summarise potentially useful research strategies, including studying the genotype of GLUT proteins with respect to schizophrenia phenotypes, activation studies involving fMRI using deoxyglucose as a substrate, and investigating clinical features of schizophrenic patients prior to and following treatment for co-existing diabetes.