کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8999781 1556715 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of naturally occurring isothiocyanates in the inhibition of cyclophosphamide-induced urotoxicity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Effect of naturally occurring isothiocyanates in the inhibition of cyclophosphamide-induced urotoxicity
چکیده انگلیسی
Cyclophosphamide-induced urotoxiciy was reduced in Swiss albino mice by the treatment of naturally occurring isothiocyanates such as AITC or PITC (25 μg/dose/animal, i.p.) for 5 days along with CTX (1.5 mmol/kg body wt.; i.p.). Severely inflamed and dark coloured urinary bladders of the CTX alone treated animals were found to be normalized on morphological analysis by the treatment of AITC or PITC. Urine protein levels were reduced by the treatment with AITC (6.2±0.37 g/l) and PITC (6.56±1.56 g/l), which was elevated by CTX administration (8.66±0.47 g/l). Urine urea N2 that was enhanced significantly by CTX administration (26.87±1.86 g/l) was reduced by treatment with both AITC (17.38±0.06 g/l) and PITC (15.85±1.56 g/l). GSH content, which was drastically reduced by CTX administration in both bladder (0.87±0.1 nmol/mg protein) and liver (2.47±0.6 nmol/mg protein) was enhanced by treatment with AITC and PITC both in bladder (AITC- 3.65±0.18 nmol/mg protein; PITC- 2.8±0.15 nmol/mg protein) and in liver (AITC- 4.10±0.81 nmol/mg protein; PITC- 4.70±0.44 nmol/mg protein). Histopathology of the bladders of CTX alone treated group showed severe necrosis of the tissue whereas AITC and PITC treated group showed normal bladder pathology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 12, Issues 6–7, 15 June 2005, Pages 487-493
نویسندگان
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