کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8999850 1116229 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure-antimicrobial activity of some natural isocoumarins and their analogues
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Structure-antimicrobial activity of some natural isocoumarins and their analogues
چکیده انگلیسی
Three naturally occurring isocoumarins (paepalantine, paepalantine 9-O-β-d-glucopyranoside and paepalantine 9-O-β-d-allopyranosyl(1→6) glucopyranoside) and two semi-synthetic analogues, 9,10-acylated compound and 9-OH-10-methylated compound, structurally similar to paepalantine, were evaluated for antimicrobial activity using a spectrophotometric microdilution technique. The paepalantine was active against S. aureus, S. epidermidis, and E. faecalis while the other four compounds proved ineffective against all microorganisms tested at concentrations of 500 μg/ml. Variations in phenolic substitution at OH-9 and/or OH-10 in the paepalantine molecule resulted in compounds without antimicrobial activity. A combination of structural features, two phenolic groups as cathecolic system, forms an oxygenated system arrangement that may reflect the potentially antimicrobial properties of paepalantine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 12, Issue 5, 16 May 2005, Pages 378-381
نویسندگان
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