Urinary Concentrations and Bactericidal Activity Against Amoxicillin-Nonsusceptible Strains of Escherichia coli with Single-Dose, Oral, Sustained-Release Amoxicillin/Clavulanic Acid: A PhaseI, Open-Label, Noncomparative Clinical Trial in Healthy Volunteer

In this Phase I study in healthy volunteers, urinary concentrations after dosing with amoxicillin/clavulanic acid 2000/125 mg SRshowed bactericidal activity against the amoxicillin-susceptible and intermediately resistant strains of E coli.