کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9007027 | 1559667 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
HPLC based activity profiling for 5-lipoxygenase inhibitory activity in Isatis tinctoria leaf extracts
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
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![عکس صفحه اول مقاله: HPLC based activity profiling for 5-lipoxygenase inhibitory activity in Isatis tinctoria leaf extracts HPLC based activity profiling for 5-lipoxygenase inhibitory activity in Isatis tinctoria leaf extracts](/preview/png/9007027.png)
چکیده انگلیسی
In the pursuit of the anti-inflammatory constituents in lipophilic woad extracts, the 5-lipoxygenase (5-LOX) inhibitory activity was investigated by HPLC-based activity profiling. In a low-resolution profiling, two time windows with peaks of activity were found. The first coincided with tryptanthrin, a known dual inhibitor of cyclooxygenase-2 (COX-2) and 5-LOX, whereas the major inhibitory fraction was towards the end of the HPLC run. The active fractions were profiled in a peak-resolved manner, and the compounds analyzed by LC-MS, GC and TLC. The activity in the lipophilic fractions of the Isatis extract could be linked to an unsaturated fatty acid, α-linolenic acid.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 76, Issues 3â4, June 2005, Pages 324-332
Journal: Fitoterapia - Volume 76, Issues 3â4, June 2005, Pages 324-332
نویسندگان
C. Oberthür, R. Jäggi, M. Hamburger,