کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9021455 | 1561374 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The yin and yang of volatile anesthetic action on cardiac potassium channels
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Volatile anesthetics have been in use for over a century but their mechanism of action at the cellular and molecular levels is yet to be elucidated. These agents have multiple targets that include ion channel proteins. Though the mechanism of volatile anesthetic action on the neuronal ligand-gated channels has been described, its action on voltage-gated channels is less well understood. Volatile anesthetics have profound effects on heart function, and have been demonstrated to impart cardioprotection against ischemia. Yet, the mechanism of volatile anesthetic action on the cardiac ion channels is limited. These agents have differential effects on the cardiac Na, Ca, and K channels. Several types of K channels contribute to cardiac excitability and repolarization of the action potential. They are also targets of cardiac and non-cardiac therapeutic agents. Defects in K channels have been linked to fatal arrhythmias and sudden death. Recently, K channels have been shown to underlie the cardioprotection by volatile anesthetics. This review will focus on some of the latest development regarding anesthetic effects on the cardiac K channels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Congress Series - Volume 1283, November 2005, Pages 96-101
Journal: International Congress Series - Volume 1283, November 2005, Pages 96-101
نویسندگان
Wai-Meng Kwok,