کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9021502 | 1561374 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anesthetic and non-anesthetic effects on interfacial lipids around an ion channel
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
All atom molecular dynamics simulations were used to investigate the anesthetic and non-anesthetic effects on the dynamics of bulk and the interfacial dimyristoylphosphatidylcholine lipids surrounding a gramicidin-A (gA) channel. Two pairs of simulations in the presence and absence of halothane and of hexafluoroethane (HFE) were carried out for 2.2 and 8 ns, respectively. The order parameters, determined from the asymptotes of the autocorrelations of the vector between the nitrogen and the immediate methylene carbon of the choline head group and the Ciâ1Â -Â Ci+1 vectors for the ith carbon (Ci) in the lipid chains, show that the head groups are less ordered in the interfacial lipids than in the bulk lipids, and that neither halothane nor HFE at 5 mol% concentration has significant effects on the ordering of the interfacial or bulk lipid chains. Because halothane and HFE produce distinctly different effects on the global dynamics of gA channel, it is unlikely that anesthetic effects on gA are indirectly mediated through the lipids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Congress Series - Volume 1283, November 2005, Pages 215-218
Journal: International Congress Series - Volume 1283, November 2005, Pages 215-218
نویسندگان
Pei Tang, Yan Xu,