Effects of sleep on cortical responses to noxious stimuli

We used magnetoencephalography (MEG) to study effects of sleep on cortical responses to noxious stimuli and to clarify the mechanisms underlying pain perception. For a noxious stimulus, painful intraepidermal electrical stimulation (ES), which selectively activates A-delta fibers, was applied to the dorsum of the left hand. While awake, subjects were asked to count the number of stimuli silently (Attention) or ignore the stimuli (Control). During sleep, magnetic fields recorded in stage 1 sleep and stage 2 sleep were analyzed. One main component at a latency around 140-160 ms was identified in the awake condition. Multiple source analysis indicated that this main component was generated by activities in the contralateral primary somatosensory cortex (SI), bilateral secondary somatosensory cortex (SII) and insular cortex. The medial temporal area (MT) and cingulate cortex were activated later than the main component. Cortical responses in the contralateral SI, ipsilateral SII and MT, bilateral insula, and cingulate cortex were significantly enhanced in Attention as compared with Control. The main component 1M, as well as later magnetic fields, was markedly attenuated during sleep, suggesting that all these cortical areas are involved in pain cognition.