کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9021949 | 1561378 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Postmenopausal hormone therapy and cancer risk
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Postmenopausal Hormone Replacement Therapy has been implicated in the development of four frequent female tumors: endometrial cancer, breast cancer, ovarian cancer and colorectal cancer. Estrogens are only weak genotoxic, mutagenic carcinogens, but could induce tumors by way of accumulation of incessant DNA replication damage. While estrogen (only) hormone replacement therapy (ERT) increases the risk of endometrial carcinoma and probably of ovarian carcinoma, ERT seems to be neutral for the breast and colorectal cancer. With combined estrogen progestagen replacement therapy (HRT), there is no increased risk of endometrial cancer nor of ovarian cancer. The risk of breast cancer, however, is slightly increased with long-term use. Colorectal cancer risk is probably reduced with combined HRT use. Data are only available for oral use; for transdermal, intranasal and other use no data are available.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Congress Series - Volume 1279, April 2005, Pages 133-140
Journal: International Congress Series - Volume 1279, April 2005, Pages 133-140
نویسندگان
P. Kenemans, R.A. Verstraeten, R.H.M. Verheijen,