Recurrent miscarriage

Factors influencing the miscarriage risk such as previous miscarriage, increased maternal age and diminished ovarian reserve are also probably the most important factors in the success rate after recurrent miscarriage (RM). The individual risk of having an abnormal karyotype is about 2.3% after two miscarriages. The relatively high incidence of miscarriages in PCO patients is most likely due to an abnormal development of the oocyte. Uterine anomaly is a rare cause of RM. Antiphospholipid syndrome, Factor V Leiden and hyperhomocystinaemia have turned out to be proven risk factors while other trombofilias do not seem to be associated with RM. In about half of all patients with recurrent miscarriage the underlying causes remain unknown.