کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9031116 | 1130968 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis
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کلمات کلیدی
Garcinia cambogiaZucker obese ratALP, alkaline phosphatase - ALP، قلیایی فسفاتازFSH, follicle-stimulating hormone - FSH، هورمون تحریک کننده فولیکولLH, luteinizing hormone - LH، هورمون لووتیونیNEFA, non-esterified fatty acid - NEFA، اسید چرب غیر استرادیلیNOAEL, no observed adverse effect level - NOAEL، هیچ اثرات جانبی مشاهده نشدTestis - بیضهTesticular toxicity - مسمومیت مزمنBUN, blood urea nitrogen - نیتروژن اوره خون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis](/preview/png/9031116.png)
چکیده انگلیسی
We investigated the ability of Garcinia cambogia extract containing (â)-hydroxycitric acid (HCA) to suppress body fat accumulation in developing male Zucker obese (fa/fa) rats. We also examined histopathologically the safety of its high doses. Diets containing different levels of HCA (0, 10, 51, 102 and 154Â mmol/kg diet) were fed to 6-week-old rats for 92 or 93 days. Each diet group was pair-fed to the 154Â mmol HCA/kg diet group. Epididymal fat accumulation and histopathological changes in tissues were observed. The highest dose of HCA-containing Garcinia cambogia (154Â mmol HCA/kg diet) showed significant suppression of epididymal fat accumulation in developing male Zucker obese rats, compared with the other groups. However, the diets containing 102Â mmol HCA/kg diet and higher (778 and 1244Â mg HCA/kg BW/d, respectively) caused potent testicular atrophy and toxicity, whereas diets containing 51Â mmol HCA/kg diet (389Â mg HCA/kg BW/d) or less did not. Accordingly, 51Â mmol HCA/kg diet (389Â mg HCA/kg BW/d) was deemed to be the no observed adverse effect level (NOAEL).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 43, Issue 3, March 2005, Pages 411-419
Journal: Food and Chemical Toxicology - Volume 43, Issue 3, March 2005, Pages 411-419
نویسندگان
M. Saito, M. Ueno, S. Ogino, K. Kubo, J. Nagata, M. Takeuchi,