Network destabilization and transition in depression: New methods for studying the dynamics of therapeutic change

• Dynamic systems theory is proposed as a framework for understanding the chronicity of depression.
• Principles of dynamic systems and modern learning theory are applied to the treatment of depression.
• A dynamic systems model of change is investigated.
• Avenues for future treatment innovation are discussed.

The science of dynamic systems is the study of pattern formation and system change. Dynamic systems theory can provide a useful framework for understanding the chronicity of depression and its treatment. We propose a working model of therapeutic change with potential to organize findings from psychopathology and treatment research, suggest new ways to study change, facilitate comparisons across studies, and stimulate treatment innovation. We describe a treatment for depression that we developed to apply principles from dynamic systems theory and then present a program of research to examine the utility of this application. Recent methodological and technological developments are also discussed to further advance the search for mechanisms of therapeutic change.