کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9087385 | 1147726 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular Biology of Opioid Analgesia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Opioids provide excellent pain relief in most patients. Yet the responses of patients to individual opioids can vary markedly, even among the μ opioids. Understanding this variability would greatly enhance our ability to treat patients appropriately. Classical pharmacological studies have long implied the existence of multiple subtypes of μ opioid receptors. More recently, a number of variants of the cloned μ opioid receptor have been described. These variants all show the same selectivity for μ opioids, confirming their classification as μ opioid receptors. Yet, they differ in their functional activation by opioids as well as in their localization within cells and regions in the brain. These multiple μ opioid receptors may help explain the range of responses seen clinically among patients for the various opioid drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pain and Symptom Management - Volume 29, Issue 5, Supplement, May 2005, Pages 2-9
Journal: Journal of Pain and Symptom Management - Volume 29, Issue 5, Supplement, May 2005, Pages 2-9
نویسندگان
Gavril W. MD, PhD,