کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9089545 | 1148678 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adverse drug reactions
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کلمات کلیدی
Type BAnaphylactoid - آنافیلاکسیAnaphylaxis - آنافیلاکسی یا بیشدفاعی Apnoea - آپنهHypotension - افت فشارخونBronchospasm - برونش اسپاسمHypersensitivity - حساسیت بیش از حدDrug - داروSuxamethonium - سکسمانتریومAdverse - غلطPharmacology - فارماکولوژی یا داروشناسیType A - نوع Amalignant hyperthermia - هیپرترمی بدخیمReactions - واکنش هاPorphyria - پورفیری
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیهوشی و پزشکی درد
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چکیده انگلیسی
Adverse drug reactions are unwanted reactions to drugs that occur under normal conditions of use, and are probably responsible for 3-5% of all hospital admissions. They are usually classified as Type A (augmented) or Type B (bizarre) reactions. Type A reactions are responsible for 80-90% of all adverse responses to drugs. They are relatively common, well known, and predictable, and have a close temporal relation with drug administration. Although patients vary in their susceptibility, most Type A reactions occur in every patient who is given the drug in sufficient dose. Type B reactions are usually unrelated to the main effects of drugs; they are often dose-independent, uncommon and unpredictable. Although their cause may be obscure, they are sometimes related to genetic predisposition or drug hypersensitivity. In anaesthetic practice, at least three important Type B reactions are directly related to genetic predisposition (malignant hyperthermia, suxamethonium apnoea, hepatic porphyria). Hypersensitivity or allergic responses to drugs depend on immunological factors; there are four types, depending on the mechanism involved. Most severe allergic reactions to drugs are a result of Type I hypersensitivity (anaphylaxis). In anaesthesia, the main aetiological factors are muscle relaxants, antibiotics, latex rubber and chlorhexidine; reactions to these agents may cause hypotension, bronchospasm, facial and laryngeal oedema, or urticaria. Similar effects occur when histamine and other factors are directly released from mast cells by non-immunological mechanisms (anaphylactoid reactions). Finally, drugs that are given during pregnancy may cross the placental barrier and adversely affect the fetus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Anaesthesia & Intensive Care Medicine - Volume 6, Issue 7, 1 July 2005, Pages 245-249
Journal: Anaesthesia & Intensive Care Medicine - Volume 6, Issue 7, 1 July 2005, Pages 245-249
نویسندگان
Norman Calvey,