Influence of Scar Tissue Formation on the Early Wound Healing Process of Palate Bones in Rats

A palatoplasty via the push-back method is applied for the patients with cleft palate. Disturbances such as impaired growth of maxilla, narrowing of the maxillary dental arch, malalignment, and lingual slanting of teeth occasionally occur as poor prognosis of this surgical method. The etiology of these complications has not been fully elucidated. In this research, mucoperiosteal scraping was experimentally performed at the palate, and the influence of the surgery on the early reparative processes of the palate was explored for 2 weeks postoperatively, both with histopathological and multiple fluorescence labeling approaches. The findings acquired were as follows: