کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9103404 | 1152676 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Autophagy as an Innate Defense System against Invading Pathogenic Bacteria
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Autophagy as an Innate Defense System against Invading Pathogenic Bacteria Autophagy as an Innate Defense System against Invading Pathogenic Bacteria](/preview/png/9103404.png)
چکیده انگلیسی
Elimination of pathogenic bacteria harbored within host cells is crucial for host defense. Many pathogenic bacteria can enter professional or nonprofessional phagocytic cells to colonize, or disseminate to other cells. The endocytic degradation of pathway has been considered the only system against such intracellular pathogens. However, there is a second degradation system within the host cells, called autophagy. Autophagy is a physiologically important cellular process for the degradation of some organelles and cytosolic proteins within cells. Several studies have shown that some intracellularly invading bacteria are found within autophagosomes, however, it is still unclear whether these bacteria are vulnerable to autophagic destruction. Recently, we found that intracellularly invaded Streptococcus pyogenes (Group A Streptococcus; GAS) were selectively trapped by the autophagosome-like compartments and degraded upon fusion with lysosomes in non-phagocytic epithelial cells. In autophagosome formation-deficient Atg 5-/- cells, such compartments were not formed upon GAS infection. These results indicate that the autophagic machinery is utilized not only for degradation of subcellular components, but also functions as an innate defense system against invading bacteria.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Oral Biosciences - Volume 47, Issue 1, 2005, Pages 11-17
Journal: Journal of Oral Biosciences - Volume 47, Issue 1, 2005, Pages 11-17
نویسندگان
Ichiro Nakagawa,