کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9103408 | 1152676 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dendritic Cells and Oral Cancer
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
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چکیده انگلیسی
The most potent antigen-presenting cells, dendritic cells (DCs), play an important role in the cellular antitumor response by taking up tumor antigens and stimulating the activity of antigen-specific T cells. The differentiation of DCs can be induced in bone marrow or peripheral blood cultures using cytokines such as granulocyte macrophage colony-stimulating factor, interleukin (IL)-4, and tumor necrosis factor-α. In recent years the application of DCs to immunotherapy has been challenged by various malignant neoplasms. It has been shown in cancer patients that cancer cells themselves produce and secrete immunosuppressive cytokines such as IL-10, transforming growth factor-β1, and vascular endothelial growth factor, which induce defective immune cell function and a defective host immune response. In this article we describe the suppression of DC differentiation and the possible application of DCs to immunotherapy in human squamous cell carcinoma of the oral cavity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Oral Biosciences - Volume 47, Issue 1, 2005, Pages 42-51
Journal: Journal of Oral Biosciences - Volume 47, Issue 1, 2005, Pages 42-51
نویسندگان
Kaoru Kusama, Masakatsu Fukuda, Kentaro Kikuchi, Mari Ishikawa, Hideaki Sakashita, Norimichi Nemoto,