کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9103525 | 1568052 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lipoxins in the eye and their role in wound healing
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کلمات کلیدی
ALXLXA4PMNLTB4lipoxin A4 receptorALOX15ALOX12ALOX5docosahexaenoic acid - اسید داکوزاگزوائونیکhydroxy-eicosatetraenoic acid - اسید هیدروکسی ایکوزاتترنوئیکLOX - اکسیژن مایعDHA - دوکوساهگزائنوئیک اسیدPlatelet activating factor - عامل فعال کننده پلاکتpolymorphonuclear neutrophil leukocyte - لکوسیت نوتروفیل چند هسته ای هسته ایlipoxygenases - لیپوکسیژنازهاlipoxin A4 - لیپوکین A4PAF - نیروی هوایی پاکستانHETE - هفته
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The eye must contain highly evolved programs to limit inflammation and promote wound healing as an errant response can lead to blindness. However, pathways that protect the delicate visual axis and account for its atypical inflammatory responses remain to be clearly defined. Hence, research efforts have been initiated to elucidate the role of the anti-inflammatory LXA4 circuits in the eye. LXA4 is formed in healthy and injured corneas and both its receptor and 12/15-lipoxygenase are predominately expressed in epithelial cells. An essential role for LXA4 in preserving ocular function is supported by 12/15-LOX deficient mice that exhibit a phenotype of impaired wound healing and LXA4 formation. A novel epithelial bioaction role for LXA4 has been uncovered in the cornea as topical LXA4 promotes wound healing and limits the sequelae of injury. These emerging studies indicate that the LXA4 circuit may hold a fundamental role in maintaining an ocular environment that actively restricts inflammation while promoting wound healing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 73, Issues 3â4, SeptemberâOctober 2005, Pages 221-229
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 73, Issues 3â4, SeptemberâOctober 2005, Pages 221-229
نویسندگان
Karsten Gronert,