کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9110728 | 1155355 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Elevated interleukin-12 and CXCL10 in subacute sclerosing panencephalitis
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Elevated interleukin-12 and CXCL10 in subacute sclerosing panencephalitis Elevated interleukin-12 and CXCL10 in subacute sclerosing panencephalitis](/preview/png/9110728.png)
چکیده انگلیسی
Immunosuppression associated with measles virus (MV) can be demonstrated by cytokine production failure in subacute sclerosing panencephalitis (SSPE) and may have implications on the pathogenesis of the disease. Cytokines (IL-12, IL-10, IL-4, IL-17, IL-18, IFN-α, IFN-γ) and chemokines (CXCL8, CXCL10, CCL2 and CCL5) were measured in the cerebrospinal fluid (CSF) and serum samples from 60 patients with SSPE, 36 patients with infectious and/or inflammatory (IN) and 28 with other non-inflammatory (NIN) neurological diseases by ELISA. IL-12 p70+p40 was elevated in CSF and sera of SSPE when compared to the NIN group. However, the CSF levels of IL-12 p70 alone were not increased, indicating an increase of p40. The CSF of SSPE patients also showed relatively higher levels of IL-10 than that of the NIN group. CXCL10 levels in CSF were significantly higher in SSPE, whereas CXCL8 was increased in sera compared to NIN. No difference was detected in IFN-γ, IFN-α, IL-17, IL-18, IL-4 or CCL2 and CCL5 levels. These results demonstrate that immune response against MV in SSPE may be impaired, although some T cell/Th1 inducing stimulations are present.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 32, Issue 2, 21 October 2005, Pages 104-110
Journal: Cytokine - Volume 32, Issue 2, 21 October 2005, Pages 104-110
نویسندگان
Güher Saruhan-Direskeneli, Candan Gürses, Veysi Demirbilek, Sibel P. Yentür, Gülden Yılmaz, Emel Ãnal, Zuhal Yapıcı, Cengiz Yalçınkaya, Ãzlem Ãokar, GülÅen Akman-Demir, AyÅen GökyiÄit,