کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9110781 | 1155365 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hepatic steatosis in the absence of tumor necrosis factor in mice
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Hepatic steatosis in the absence of tumor necrosis factor in mice Hepatic steatosis in the absence of tumor necrosis factor in mice](/preview/png/9110781.png)
چکیده انگلیسی
Tumor necrosis factor (TNF) has pleiotropic effects including on hepatic metabolism. Here we investigated the effect of high cholesterol diet (1.25%) in TNF deficient mice. TNFα/β deficient mice developed hepatomegaly and extensive steatosis in the absence of steatohepatitis as compared to wild type mice. Saturated and unsaturated, prominently mono- but also poly-unsaturated fatty acids (MUFA, PUFA) prevailed in steatotic livers. Down-regulation of the cholesterol scavenger receptor B1 and reduced insulin induced phosphorylation of protein kinase B in cholesterol fed TNFα/β deficient mice likely contributed to the development of hepatic steatosis, which was accompanied by increased body weight and bone length. Steatosis was only present in TNFα/β double deficient mice, however not in single TNF deficient mice suggesting a redundant role of TNFα and TNFβ. In conclusion, high cholesterol diet causes an abnormal metabolic phenotype in the simultaneous absence of both TNFα and β signals. The presence of either TNFα or β alone is sufficient to reconstitute the control of lipid homeostasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 32, Issue 6, 21 December 2005, Pages 287-295
Journal: Cytokine - Volume 32, Issue 6, 21 December 2005, Pages 287-295
نویسندگان
Silvia Schnyder-Candrian, Janusz Czarniecki, Stephanie Lerondel, Josef Corpataux, Bernhard Ryffel, Bruno Schnyder,