کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9110810 | 1155370 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibitory effects of interferon-γ on myocardial hypertrophy
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
Prostaglandin F2α (PGF2α) plays an important role in pathologic cardiac growth. After testing several immune cytokines, we found that interferon-γ (IFN-γ) inhibited responsiveness of adult myocytes to PGF2α. The present study was designed to test the hypothesis that IFN-γ inhibits cardiac hypertrophy induced by PGF2α. Incubation of cultured adult rat cardiac myocytes with PGF2α caused cell spreading, which was inhibited by IFN-γ. The inhibitory effect was not affected by nitric oxide (NO) synthase inhibitors. In addition, administration of fluprostenol, a more selective agonist at the PGF2α receptor, induced cardiac hypertrophy in rats. Chronic treatment with IFN-γ inhibited this myocardial growth, and the inhibitory effect of IFN-γ was not accompanied by an increase in myocardial NO synthase gene expression. Further, abdominal aortic constriction resulted in a substantial increase in heart, ventricular and left ventricular weights to BW ratio that was significantly attenuated by treatment with IFN-γ. The results demonstrate that IFN-γ inhibits the in vitro and in vivo effects of PGF2α on cardiac hypertrophy, and that the mechanism of action is likely independent of NO production. IFN-γ also attenuated cardiac hypertrophy induced by pressure overload, suggesting that PGF2α plays a role in the pathogeneses of this severe type of cardiac hypertrophy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 31, Issue 6, 21 September 2005, Pages 405-414
Journal: Cytokine - Volume 31, Issue 6, 21 September 2005, Pages 405-414
نویسندگان
Hongkui Jin, Wei Li, Renhui Yang, Annie Ogasawara, Hsienwie Lu, Nicholas F. Paoni,