کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9110857 | 1568751 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CXC chemokines modulate IgE secretion and pulmonary inflammation in a model of allergic asthma
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کلمات کلیدی
AHRCRABALMCHHDEhouse dust extractCockroach allergen - آلرژن سوسریAllergy - آلِرژیPulmonary inflammation - التهاب ریهbronchoalveolar lavage - لارو برونکلو آلوئولارlipopolysaccharide - لیپوپلی ساکاریدenhanced pause - مکث طولانیNeutrophils - نوتروفیل هاAirway hyperresponsiveness - پاسخگویی فوریPenh - پناهChemokines - کرموین ها
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
The pathophysiology of asthma is influenced by exposure to allergens and endotoxin. Although the role of allergen-induced eosinophilia has been widely studied, neutrophil-mediated responses remain elusive. A role for neutrophils in the asthmatic responses is likely since human neutrophils have been shown to express IgE receptors, as well as receptors for many cytokines and chemokines implicated in the pathogenesis of asthma. In this study we investigated neutrophil involvement in a novel, house dust extract (HDE) induced model of asthma-like pulmonary inflammation. Mice were immunized and challenged with HDE containing high levels of cockroach allergens, 377 U/ml Bla g1 and 6249 ng/ml Bla g2. The biological activity of the murine chemokines KC and MIP-2 was inhibited with specific rabbit antisera. Differential counting of cells recovered from the bronchoalveolar lavage (BAL) fluid showed that neutralization of KC and MIP-2 significantly decreased pulmonary recruitment of neutrophils (reduced 86%) and lymphocytes (reduced 76%). Neutralization of these chemokines also exerted a systemic effect with a significant decrease in plasma IgE levels, 547 ng/ml ± 65 compared to 1314 ng/ml ± 247 for control sera treated animals. This study shows that CXC chemokines play an important role in allergy and asthma both at the level of pulmonary cell recruitment and systemic immune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 32, Issues 3â4, November 2005, Pages 178-185
Journal: Cytokine - Volume 32, Issues 3â4, November 2005, Pages 178-185
نویسندگان
Laura McKinley, Jiyoun Kim, Gerald L. Bolgos, Javed Siddiqui, Daniel G. Remick,