کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9110878 | 1155374 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of blood storage conditions on leucocyte intracellular cytokine production
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
In cell cultures stored at RT or 4 °C for 24 h, significant changes in several leucocyte cytokines/chemokines were shown compared to blood cultures stimulated at time = 0. There was a significant decrease in IL-2, IL-4 and TNFα production by CD4+ T cells in blood cultures stored at RT but an increase in IL-2 in cultures at 4 °C. There was a significant decrease in TGFβ production by CD4+ and CD8+ T cells in cultures kept at RT or 4 °C. There was a significant increase in MCP-1 and MCP-3 production by monocytes in blood cultures kept at RT or 4 °C. There was a decrease in IL-12 production by monocytes in cultures kept at 4 °C, whereas IL-10 production was decreased at RT and increased in cultures kept at 4 °C. Blood stored at 4 °C showed less immunomodulatory changes than blood kept at RT although overall a possible Th1 bias at 4 °C.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 32, Issue 1, 7 October 2005, Pages 7-11
Journal: Cytokine - Volume 32, Issue 1, 7 October 2005, Pages 7-11
نویسندگان
G. Hodge, C. Markus, J. Nairn, S. Hodge,