Negligible induction of IFN-γ, IL-12 and TNF-α by DNA-PEI 750 kDa/albumin complexes

High gene transfer capability and a relatively low pro-inflammatory response of 750 kDa PEI/albumin/DNA complexes can be exploited for recurrent gene transfer into lungs to treat (via inhalation or instillation) cancer or genetic disorders such as cystic fibrosis.