کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9110920 1155378 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationship between cerebral injury and inflammatory responses in patients undergoing cardiac surgery with cardiopulmonary bypass
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Relationship between cerebral injury and inflammatory responses in patients undergoing cardiac surgery with cardiopulmonary bypass
چکیده انگلیسی
This study was performed to evaluate whether cytokines, adhesion molecules, ghrelin and S-100B are useful markers in predicting the cerebral infarction after cardiac surgery with cardioplumomary bypass (CPB). The patients (n = 20) were classified into two groups; group A (n = 4) showed postoperative organized cerebral damage, while group B (n = 16) consisted of patients without occurrence of postoperative strokes. Before CPB, serum levels of S-100B in both groups A and B were low (<0.5 ng/mL), while ghrelin concentrations in group A (all patients had history of strokes) were much higher than those in group B. After CPB, when serum levels of S-100B in group A at 24 h were higher than those in group B, ghrelin in group A at same time point showed high levels in comparison to group B. At 12 and 24 h after CPB, levels of tumor necrosis factor (TNF)-α, interleukin-10 and soluble TNF-receptor I in group A were significantly higher than those in group B. In conclusion, it is considered that ghrelin as well as S-100B can be a useful marker for the prediction of stoke after CPB. Increase of TNF-α, interleukin-10 and soluble TNF-receptor I after CPB may be involved in the pathogenesis of stroke after CPB.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 29, Issue 3, 7 February 2005, Pages 95-104
نویسندگان
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