کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9113195 1568935 2005 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Trends in the evolution of the proopiomelanocortin gene
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Trends in the evolution of the proopiomelanocortin gene
چکیده انگلیسی
The POMC gene is perhaps the most extensively studied member of the opioid/orphanin gene family. In Phylum Chordata this gene has been characterized in representatives of every class within the Gnathostomata, as well as in one representative agnathan vertebrate, the marine lamprey. This review provides a systematic overview of trends in the evolution of the melanocortins (ACTH/α-MSH, β-MSH, γ-MSH, and δ-MSH) and β-endorphin in gnathostomes, and advances the hypothesis that the appearance of γ-MSH occurred early in the radiation of the gnathostomes. A summary of the extensive work on POMC genes in the marine lamprey is also provided, as well as a reevaluation of the conserved regions in the sequence of CLIP (corticotropin-like-intermediate lobe peptide) in the POMC sequences of the various groups of gnathostomes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 142, Issues 1–2, 15 May 2005, Pages 81-93
نویسندگان
, ,