کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9115137 | 1156908 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased interleukin-18 content and angiogenic activity of sera from diabetic (Type 2) patients with background retinopathy
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of the present work was an examination of IL-18 concentration in the sera of elderly DM2 patients with nonproliferative retinopathy and age-matched control people and an estimation whether this cytokine plays pro- or anti-angiogenic role in in vivo angiogenic activity of their sera in mice cutaneous angiogenesis test. Recombinant human IL-18 injected intradermally to murine skin induced significant neovascular reaction. DM2 patients sera contained higher concentration of IL-18 and induced stronger neovascular reaction in mice skin than did the sera of corresponding control people. Sera from both groups of people after neutralization with antihuman IL-18 antibodies lost substantial part of their angiogenic activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Diabetes and its Complications - Volume 19, Issue 6, NovemberâDecember 2005, Pages 335-338
Journal: Journal of Diabetes and its Complications - Volume 19, Issue 6, NovemberâDecember 2005, Pages 335-338
نویسندگان
Piotr SkopiÅski, Ewa Rogala, Barbara Duda-Król, Anna LipiÅska, Ewa Sommer, Joanna Chorostowska-Wynimko, Jerzy Szaflik, Iwona Partyka, Ewa SkopiÅska-Różewska,