کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9118725 | 1157773 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adrenomedullin gene expression and levels in the cardiovascular system after treatment with lipopolysaccharide
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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![عکس صفحه اول مقاله: Adrenomedullin gene expression and levels in the cardiovascular system after treatment with lipopolysaccharide Adrenomedullin gene expression and levels in the cardiovascular system after treatment with lipopolysaccharide](/preview/png/9118725.png)
چکیده انگلیسی
To study the effect of septicaemia, the temporal changes in tissue adrenomedullin (AM) and preproAM mRNA levels were studied in the heart and blood vessels after lipopolysaccharide (LPS) injection. Radioimmunoassay and solution hybridization-RNase protection assays were used to follow the changes in AM and its mRNA levels respectively after intraperitoneal injection of 10 mg/kg LPS in rats. The preproAM mRNA levels increased at 1 h in the right atrium after LPS injection, while the AM contents decreased at 1 h in the left atrium. The preproAM mRNA levels increased at 3 and 6 h in the left ventricle, whereas it increased at 6 h in the right ventricles after LPS injection. There was an increase in preproAM mRNA levels at 1 and 3 h in the mesenteric artery, while AM levels were increased at 1, 3 and 6 h. However, there were no such changes in the thoracic aorta. There were also increases in tumour necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6 in the heart, and in the mesenteric artery (TNF-α and IL-1β) and in thoracic aorta (IL-1β and IL-6). The present results suggest that the biosynthesis and secretion of AM may be increased in cardiovascular tissues of rats injected with LPS, and that AM may play multiple roles in inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropeptides - Volume 39, Issue 2, April 2005, Pages 73-80
Journal: Neuropeptides - Volume 39, Issue 2, April 2005, Pages 73-80
نویسندگان
Yuk-Yin Li, Bernard M.Y. Cheung, Louisa Y.F. Wong, Isabel S.S. Hwang, Cyrus R. Kumana, Fai Tang,