کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9121746 | 1159196 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
ADAMs are present in fungi: Identification of two novel ADAM genes in Aspergillus fumigatus
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: ADAMs are present in fungi: Identification of two novel ADAM genes in Aspergillus fumigatus ADAMs are present in fungi: Identification of two novel ADAM genes in Aspergillus fumigatus](/preview/png/9121746.png)
چکیده انگلیسی
The ADAMs are a family of integral membrane proteases involved in shedding and fusion events in animal tissues. Here, we report the identification of two ADAMs, ADM-A and ADM-B, in the pathogenic fungus Aspergillus fumigatus. The domain structure of metazoan ADAMs was seen in ADM-A and -B, although with some differences. ADAMs were identified in other filamentous fungi and phylogenetic analysis indicated that the fungal ADAMs were monophyletic and most closely related to metazoan ADAM 10 and 17. Recombinant ADM-B protease specifically cleaved casein and albumin while recombinant propeptide + protease was inactive. A sheddase function is therefore proposed for fungal ADAMs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEMS Microbiology Letters - Volume 248, Issue 1, 1 July 2005, Pages 23-30
Journal: FEMS Microbiology Letters - Volume 248, Issue 1, 1 July 2005, Pages 23-30
نویسندگان
Sandra E. Lavens, Núria Rovira-Graells, Mike Birch, Danny Tuckwell,