کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9122137 1159205 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transmission of Chlamydia pneumoniae infection from blood monocytes to vascular cells in a novel transendothelial migration model
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Transmission of Chlamydia pneumoniae infection from blood monocytes to vascular cells in a novel transendothelial migration model
چکیده انگلیسی
Chlamydia pneumoniae uses blood monocytes (PBMC) for systemic dissemination, persists in atherosclerotic lesions, and has been implicated in the pathogenesis of atherosclerosis. During transmigration in a newly developed transendothelial migration model (TEM) C. pneumoniae-infected PBMC spread their infection to endothelial cells. Transmigrated PBMC retained their infectivity and transmitted the pathogen to smooth muscle cells in the lower chamber of the TEM. Detection of chlamydial HSP60 mRNA proved pathogen viability and virulence. We conclude that PBMC can spread chlamydial infection to vascular wall cells and we suggest the TEM as a novel tool to analyze host-pathogen interactions in vascular chlamydial infections.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEMS Microbiology Letters - Volume 242, Issue 2, 15 January 2005, Pages 203-208
نویسندگان
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