کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9127120 | 1569972 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protein diversity is generated within the motin family of proteins by alternative pre-mRNA splicing
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کلمات کلیدی
HUVECECLAMOTL1Amot - آموتangiomotin - آنژیوموتینangiomotin-like 1 - آنژیوموتین مانند 1Angiogenesis - آنژیوژنزEST - استIsoform - ایسوفورenhanced chemiluminescence - بهبود شیمیایی لومنExpressed sequence tags - تگ های توالی بیان شدهGenomic organization - سازمان ژنومیpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازGene - ژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
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![عکس صفحه اول مقاله: Protein diversity is generated within the motin family of proteins by alternative pre-mRNA splicing Protein diversity is generated within the motin family of proteins by alternative pre-mRNA splicing](/preview/png/9127120.png)
چکیده انگلیسی
The motin family of proteins is comprised of three polypeptides, angiomotin, angiomotin-like 1, and angiomotin-like 2. Angiomotin is an angiostatin-binding protein that promotes endothelial cell motility and is involved in angiogenesis. The function of human angiomotin-like-1 and angiomotin-like-2, however, remains unknown. In this report, we investigated the potential for molecular diversity within the motin family of proteins through the identification and characterization of alternatively spliced transcripts in endothelial cells, human tissues and a variety of cell lines. We report that the motins display variability at the mRNA level suggesting an intricate regulatory system at the transcriptional and potentially protein level. Some alternative transcripts are expressed in a tissue-specific manner and others give rise to novel protein isoforms. The alternative splicing that occurs within this protein family may have important implications in the regulation of the expression and function of the motins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 350, Issue 2, 9 May 2005, Pages 137-148
Journal: Gene - Volume 350, Issue 2, 9 May 2005, Pages 137-148
نویسندگان
Julie Moreau, Mathieu Lord, Maryse Boucher, Pascal Belleau, Maria J.G. Fernandes,