کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9127144 | 1569975 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparative evolutionary analysis of olfactory receptor gene clusters between humans and mice
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کلمات کلیدی
Birth-and-death process - فرآیند تولد و مرگMolecular phylogeny - فیلوژنی مولکولیMHC - مجموعه سازگاری بافتی اصلیmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیMegabase(s) - مگاباز (ها)neighbor-joining - پیوستن همسایهComparative genomics - ژنومیک تطبیقیkilobase(s) - کیلو بایت (ها)olfactory receptor - گیرنده بویایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Olfactory receptor (OR) genes form the largest multigene family in mammalian genomes. Humans have â¼800 OR genes, but >50% of them are pseudogenes. By contrast, mice have â¼1400 OR genes and pseudogenes are â¼25%. To understand the evolutionary processes that shaped the difference of OR gene families between humans and mice, we studied the genomic locations of all human and mouse OR genes and conducted a detailed phylogenetic analysis using functional genes and pseudogenes. We identified 40 phylogenetic clades with high bootstrap supports, most of which contain both human and mouse genes. Interestingly, a particular clade contains â¼100 pseudogenes in humans, whereas the numbers of pseudogenes are <20 for most of the mouse clades. We also found that the organization of OR genomic clusters is well conserved between humans and mice in many chromosomal locations. Despite the difference in the numbers of genes, the numbers of large genomic clusters are nearly the same for humans and mice. These observations suggest that the greater OR gene repertoire in mice has been generated mainly by tandem gene duplication within each genomic cluster.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 346, 14 February 2005, Pages 13-21
Journal: Gene - Volume 346, 14 February 2005, Pages 13-21
نویسندگان
Yoshihito Niimura, Masatoshi Nei,