کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9137540 | 1162483 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
HIV interaction with endosomes in macrophages and dendritic cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
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چکیده انگلیسی
The human immunodeficiency virus type 1 (HIV-1) is an enveloped retrovirus that undergoes assembly at specific sites in infected cells. In macrophages, at least, this assembly occurs primarily on a subset of endocytic organelles that contain some of the markers found in late endosomes or multivesicular bodies (MVBs), in particular CD63. The budding of virus particles into endosomes has many features in common with the formation of exosomes and some limited biochemical comparison of HIV-1 particles produced from macrophages with exosomes suggests that the two have similar cellular origins. Here we show that macrophages infected with HIV contain large intracellular pools of infectious virus that can be released by homogenisation of intact cells. Immunoprecipitation experiments indicate this virus has a similar complement of cellular membrane proteins to viruses that can be recovered from the extracellular medium, further suggesting that viruses released from macrophages initially bud into endosomal organelles and are then released by fusion of these organelles with the plasma membrane.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Cells, Molecules, and Diseases - Volume 35, Issue 2, SeptemberâOctober 2005, Pages 136-142
Journal: Blood Cells, Molecules, and Diseases - Volume 35, Issue 2, SeptemberâOctober 2005, Pages 136-142
نویسندگان
Beatrice Kramer, Annegret Pelchen-Matthews, Magdalena Deneka, Eduardo Garcia, Vincent Piguet, Mark Marsh,