کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9137754 | 1162495 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Direct stimulation of naïve T cells by antigen-presenting cell vesicles
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
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چکیده انگلیسی
T cells are activated through T cell receptor (TCR) recognition of peptidic fragments of antigen bound to major histocompatibility complex (MHC) molecules on antigen-presenting cells (APC). In addition, T cells require a costimulatory signal delivered through contact with other ligands on APC, especially B7 and ICAM-1 which bind to CD28 and LFA-1, respectively, on T cells. Under physiological conditions, T cell activation requires contact with viable APC. Under defined conditions, however, T cells can be activated by exosomes secreted by APC. Evidence will be presented that exosomes can be directly immunogenic for CD8+ T cells in the absence of normal APC with the proviso that exosomes express a high density of MHC I/peptide complexes as well as B7 and ICAM-1. Similar findings apply to plasma membrane fragments prepared from APC sonicates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Cells, Molecules, and Diseases - Volume 35, Issue 1, JulyâAugust 2005, Pages 17-20
Journal: Blood Cells, Molecules, and Diseases - Volume 35, Issue 1, JulyâAugust 2005, Pages 17-20
نویسندگان
Jonathan Sprent,