کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9138880 | 1162817 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Crystal structure of TM1457 from Thermotoga maritima
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Crystal structure of TM1457 from Thermotoga maritima Crystal structure of TM1457 from Thermotoga maritima](/preview/png/9138880.png)
چکیده انگلیسی
The crystal structure of a hypothetical protein, TM1457, from Thermotoga maritima has been determined at 2.0Â Ã
resolution. TM1457 belongs to the DUF464 family (57 members) for which there is no known function. The structure shows that it is composed of two helices in contact with one side of a five-stranded β-sheet. Two identical monomers form a pseudo-dimer in the asymmetric unit. There is a large cleft between the first α-helix and the second β-strand. This cleft may be functionally important, since the two highly conserved motifs, GHA and VCAXV(S/T), are located around the cleft. A structural comparison of TM1457 with known protein structures shows the best hit with another hypothetical protein, Ybl001C from Saccharomyces cerevisiae, though they share low structural similarity. Therefore, TM1457 still retains a unique topology and reveals a novel fold.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Structural Biology - Volume 152, Issue 2, November 2005, Pages 113-117
Journal: Journal of Structural Biology - Volume 152, Issue 2, November 2005, Pages 113-117
نویسندگان
Dong Hae Shin, Yun Lou, Jaru Jancarik, Hisao Yokota, Rosalind Kim, Sung-Hou Kim,