کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9140067 | 1163395 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development](/preview/png/9140067.png)
چکیده انگلیسی
As the malarial parasite Plasmodium falciparum develops inside the erythrocyte, parasite-derived membrane structures, referred to as Maurer's clefts, play an important role in parasite development by delivering parasite proteins to the host cell surface, and participating in the assembly of the cytoadherence complex, essential for the pathogenesis of cerebral malaria. PfSBP1 is an integral membrane protein of the clefts, interacting with an erythrocyte cytosolic protein, identified here as the human Lantibiotic synthetase component C-like protein LANCL1. LANCL1 is specifically recruited to the surface of Maurer's clefts in P. falciparum mature blood stages. We propose that the interaction between PfSBP1 and LANCL1 is central for late steps of the parasite development to prevent premature rupture of the red blood cell membrane.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Biochemical Parasitology - Volume 141, Issue 1, May 2005, Pages 39-47
Journal: Molecular and Biochemical Parasitology - Volume 141, Issue 1, May 2005, Pages 39-47
نویسندگان
Thierry Blisnick, Laetitia Vincensini, Jean Christophe Barale, Abdelkader Namane, Catherine Braun Breton,