کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9141686 | 1163865 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation
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کلمات کلیدی
MFISHPKirILTITIMCD8CFSEnaïve T cellLAIR-1Ig-like transcriptLRCKiller cell Ig-like receptorcarboxy-fluorescein diacetate succinimidyl esterimmunoreceptor tyrosine-based inhibition motif - ایمنی گیرنده تیتروزین مبتنی بر انگیزه انگیزهmean fluorescence intensity - میانگین شدت فلورسانسinhibitory receptor - گیرنده مهار کننده
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
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چکیده انگلیسی
Human leukocyte-associated Ig-like receptor-1 (LAIR-1) is a transmembrane glycoprotein with a single extracellular Ig-like domain and a cytoplasmic tail containing two immunoreceptor tyrosine-based inhibition motifs (ITIMs). It is constitutively expressed on the majority of human mononuclear leukocytes and functions as an inhibitory receptor. In this study, we show that freshly isolated peripheral blood T cells are heterogeneous in their expression levels of LAIR-1. We have found that naive T cells express the highest levels of LAIR-1, even more than memory cells. The cross-linking of LAIR-1 inhibits T cell receptor (TCR) mediated signals in freshly isolated human naive T cells and whole populations of CD4+ or CD8+ T cells. TCR cross-linking increased cell surface expression of LAIR-1 in a process that requires p38 MAP kinase and ERK signaling. Altogether, these results indicate that LAIR-1 is capable of negatively regulating T cell functions, and its high level of expression by naive T cells suggests that it may function at an early stage in the development of an immune response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 42, Issue 12, August 2005, Pages 1521-1530
Journal: Molecular Immunology - Volume 42, Issue 12, August 2005, Pages 1521-1530
نویسندگان
Kerima Maasho, Madhan Masilamani, Robert Valas, Simana Basu, John E. Coligan, Francisco Borrego,