کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9152188 | 1571357 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The distribution of ventilation during bronchoconstriction is patchy and bimodal: A PET imaging study
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The distribution of ventilation during bronchoconstriction is patchy and bimodal: A PET imaging study The distribution of ventilation during bronchoconstriction is patchy and bimodal: A PET imaging study](/preview/png/9152188.png)
چکیده انگلیسی
Recent PET imaging data from bronchoconstricted sheep (Vidal Melo et al., 2005) showed that VË/QË distributions were bimodal and topographically patchy, but including a substantial heterogeneity at scales <2.2Â ml. In this paper, we reanalyze the experimental data to establish the contribution of ventilation (VËr) heterogeneity to the bimodality in VË/QË. This analysis demonstrates that the distribution of VËr during bronchoconstriction was bimodal with large patches of severe hypoventilation occupying an average of 41% of the imaged lung. The degree of hypoventilation to these regions was highly correlated with the degree of oxygenation impairment, but was quite variable amongst animals in spite of consistent degrees of mechanical obstruction. Remarkably, those regions were found to be hyperventilated before methacholine and their degree of hyperventilation was correlated with their degree of hypoventilation during bronchoconstriction. These data suggest that improving the uniformity of ventilation at baseline may be a desirable therapeutic target if the risk of severe hypoxemia during asthma attacks is to be minimized and/or the distribution of inhaled pharmaceuticals is to be optimized.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 148, Issues 1â2, 25 August 2005, Pages 57-64
Journal: Respiratory Physiology & Neurobiology - Volume 148, Issues 1â2, 25 August 2005, Pages 57-64
نویسندگان
Jose G. Venegas, Tobias Schroeder, Scott Harris, R. Tilo Winkler, Marcos F. Vidal Melo,