کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9152237 1167440 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Heterogeneity of brainstem blood flow response to hypoxia in the anesthetized rat
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Heterogeneity of brainstem blood flow response to hypoxia in the anesthetized rat
چکیده انگلیسی
Cerebral blood flow is strictly regulated during hypoxic stress. Because of the preponderant role of the brainstem in cardiorespiratory controls, blood flow response to hypoxia is stronger in this region than in the cortex. However, the brainstem is made up of various regions which differ in their responsiveness to chemical stimuli. The objective of this study was to evaluate the distribution of blood flow during hypoxia using microsphere deposition methods in three brainstem regions containing key structures in cardiorespiratory controls: the nucleus tractus solitarus (NTS), the ventral respiratory groups (VRG) and the pontine respiratory groups (PRG). Microsphere injections were made during normoxia (FIO2=0.21) and after 15 min of hypoxia (FIO2=0.21). Based on this index, blood flow increase during hypoxia was higher in the VRG than in the dorsal part of the brainstem, containing the NTS and the PRG (P = 0.002, n = 10). These results suggest that blood flow response to hypoxia favours O2 delivery in brainstem regions involved in respiratory rhythm generation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 147, Issue 1, 12 May 2005, Pages 117-122
نویسندگان
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