کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9173701 1179960 2005 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential effects of orbital and laminar shear stress on endothelial cells
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Differential effects of orbital and laminar shear stress on endothelial cells
چکیده انگلیسی
The perfect in vitro model to study and assess treatments for atherosclerosis and neointimal hyperplasia does not exist. An extensive body of literature describing effects of laminar shear stress on endothelial cells has contributed to our understanding of the interactions between shear stress and blood vessels. Laminar shear stress is atheroprotective, whereas oscillatory or disturbed shear stress correlates with areas of atherosclerosis and neointimal hyperplasia in vivo. This study describes the orbital shear stress model, its effects on endothelial cell proliferation and apoptosis, and suggests that activation of the intracellular Akt pathway is associated with these differing effects of laminar and orbital shear stress on endothelial cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Vascular Surgery - Volume 41, Issue 5, May 2005, Pages 869-880
نویسندگان
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